Hastings Center Report, Volume 52, Issue S1, Page S83-S88, March‐April 2022.

Near the beginning of In Toga Candida, Cicero informed his audience of a private meeting between his two most serious competitors for the consulate and the managers of their campaigning funds. This meeting took place at the house of a nobleman whom Cicero did not name but to whom he attributed a signal notoriety in the practice of electoral corruption. Asconius offers a solution without hesitation: it was at the house of either Caesar or Crassus. He explains his choice: these (...) two men were Cicero's most committed and influential opponents in his campaign for the consulate, and he has excellent evidence for their opposition: Cicero's own Expositio consiliorum suorum, no longer extant. The credibility or otherwise of this controversial work must be dismissed from any enquiry into the identity of the mysterious figure, however. Asconius, in naming the two alternative possibilities, discloses himself to be without authoritative evidence on the point. Nothing can have been said in De consiliis suis to identify the house, the meeting, or the notorious nobleman. Asconius' words reveal that his attempt at an identification is based on Cicero's assertion therein of an overt hostility to him on the part of both Crassus and Caesar during the campaign. His attribution of a covert ‘dirty tricks’ operation to one of them is no more than speculation. (shrink)

PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

Recent studies suggest that a non‐isotopic in situ hybridisation (NISH) approach can be successfully employed to investigate the carrier status of female relatives in families of selected patients with Duchenne muscular dystrophy (DMD) or Hunter syndrome, whose diseases are due to a specific X chromosome deletion.Whilst the majority of metaphase spreads from normal females show specific hybridisation signals on both X chromosomes when tested with either dystrophin or Hunter gene‐derived probes, only one X chromosome in each metaphase spread will show (...) the relevant hybridisation complex in female carriers of deletions involving the dystrophin or Hunter gene.Thus, the NISH method can be a valuable diagnostic tool for the detection of the carrier status of female relatives of patients with X chromosome deletions. (shrink)

Recent, well-publicized scandals, involving unethical conduct have rekindled interest in academic misconduct. Prior studies of academic misconduct have focussed exclusively on situational factors (e.g., integrity culture, honor codes), demographic variables or personality constructs. We contend that it is important to also examine how␣these classes of variables interact to influence perceptions of and intentions relating to academic misconduct. In a sample of 217 business students, we examined how integrity culture interacts with Prudence and Adjustment to explain variance in estimated frequency of (...) cheating, suspicions of cheating, considering cheating and reporting cheating. Age, integrity culture, and personality variables were significantly related to different criteria. Overall, personality variables explained the most unique variance in academic misconduct, and Adjustment interacted with integrity culture, such that integrity culture had more influence on intentions to cheat for less well-adjusted individuals. Implications for practice are discussed and future research directions are offered. (shrink)

Poor people predominate as a subgroup of those who take part in healthy volunteer research. They are subjected to minimised but unknown risks and unpleasant burdens so that the safety of new medicines can be evaluated. This is prima facie unfair especially given that the poor are often unable to access expensive medicines. Although participants in this kind of research often do receive compensation for their time, these payments are usually capped at a very low level. This paper defends a (...) version of a reimbursement model for the payment of research subjects. This model is practical, would benefit those without an income who take part in research, and would make it possible for those in regular work to take part in phase 1 research. (shrink)

Traditional approaches to measurement of violations of academic integrity may overestimate the magnitude and severity of cheating and confound panic with planned cheating. Differences in the severity and level of premeditation of academic integrity violations have largely been unexamined. Results of a study based on a combined sample of business students showed that students are more likely to commit minor cheating offenses and engage in panic-based cheating as compared to serious and planned cheating offenses. Results also indicated there is a (...) significant interaction between severity and type of cheating. We hypothesized serious and planned cheating offenses would be related to justifications and found the largest differences were between panic and planned. Finally, panic and minor cheating were associated with two self-control-related personality traits. Implications for cheating research are discussed. (shrink)

Academic misconduct is widespread in schools, colleges, and universities and it appears to be an international phenomenon that also spills over into the workplace. To this end, while a great deal of research has investigated various individual components such as, demographic, personality and situational factors that contribute to cheating, research has yet to examine why students help others cheat and which students are being asked to help others cheat. In this study, we investigated if the closeness of the relationship to (...) the individual requesting help in cheating to the individual being asked to help cheat, influenced the decision to help cheat. We also investigated if past cheating behavior predicted how an individual would respond to requests to cheat. Additionally, we sought to answer the following questions; whether minor cheating is more prevalent than serious cheating, what personality factors predict helping others cheat, who is helped, and how people rationalize helping others cheat. Results indicate minor cheating to be more prevalent, prudent personalities are less likely to have cheated or to help others cheat, individuals are more likely to help friends cheat than to help strangers, and past cheating behaviors is indicative of helping others to cheat. Implications for research and practice are discussed. (shrink)

In face-to-face interaction, speakers make multimodal contributions that exploit both the linguistic resources of spoken language and the visual and spatial affordances of gesture. In this paper, we argue that, in formulating and understanding such multimodal contributions, interlocutors apply the same principles of coherence that characterize the interpretation of natural language discourse. In particular, we use a close analysis of a series of naturally-occurring embodied discourses to argue for two key generalizations. First, communicators and their audiences draw on coherence relations (...) to establish interpretive connections between successive gestures and between gestures and speech. Second, coherence relations facilitate meaning-making by resolving the underspecified meaning of each communicative act through constrained inference over entities, propositions, and spatial frames made salient in the prior discourse. Our approach to gesture interpretation improves on previous work in better accounting for its flexibility, in capturing its constraints, and in laying the groundwork for formal and computational models. At the same time, it shows that gesture provides an important source of evidence to sharpen the theory of coherence relations and contextual resolution. (shrink)

What is the will? And what is its relation to human action? Throughout history, philosophers have been fascinated by the idea of 'the will': the source of the drive that motivates human beings to act. However, there has never been a clear consensus as to what the will is and how it relates to human action. Some philosophers have taken the will to be based firmly in reason and rational choice, and some have seen it as purely self-determined. Others have (...) replaced the idea of the human will with a more general drive uniting humans and the rest of nature, living and non-living. This collection of nine specially commissioned papers trace the formulation and treatment of the problem of the will from ancient philosophy through the scholastic theologians of the Middle Ages, to modern philosophy, and right up to contemporary theories. Philosophers discussed include Plato, Aristotle, Augustine, Aquinas, Bonaventure, Hobbes, Kant, Schopenhauer and Nietzsche. (shrink)

This chapter contains section titled: I Aristotle and Early Modern Philosophy II Medieval Thought in Early Modern Scholasticism III The Philosophical Textbook IV Conclusions.

Orthodox ideas of ownership tend to depict property as a private domain that expresses the owner?s formal rights. Yet equity does much to resist this outlook, deploying ethically-loaded ideas such as conscience and articulating an interpersonal and distinctly duty-driven character to property relations. Focusing on English case law, this article suggests that we can gather various strands of equitable property norms, particularly those derived from the constructive trust, around relationships of responsibility and vulnerability. Furthermore, the article asks what such equitable (...) ideas about property might therefore tell us about the purportedly possessive character of human subjectivity. Rather than constructing people as sovereign, autonomous proprietors, we might read equity as tracing an ethical quality to the way we perceive ourselves and others through property-related ideas. (shrink)

Jurisprudential debates on the place of law within the concept of anarchy are limited. Welack thorough arguments on whether law is negated by this concept, or whether anarchy requiressome kind of specific legal organisation. This article seeks to help enliven such discourse by exploring Emmanuel Levinas?s writings on the subject. Levinas?s account of anarchy as anirreducible and emancipatory ingredient of human subjectivity has the nuance capable of addressing the contradictions that dog any attempt to philosophise an anarchic account of the (...) law. Ultimately, it will be argued that Levinas allows us to think of anarchy not as requiring the expunging or co-optionof law, but as connected to law in a mode of perpetual ethical resistance. (shrink)

Extensive regions of chromosomes can be transcriptionally repressed through silencing mechanisms mediated by complex chromatin structures. One of the most refined molecular portraits of silenced chromatin comes from studies of the silent mating‐type loci and telomeres of S. cerevisiae. In this budding yeast, the Sir3p silent information regulator emerges as a critically important silencing component that interacts with nucleosomes and other silencing proteins. Not only is it essential for silencing, but Sir3p is also capable of spreading silenced chromatin when its (...) dosage is increased. Sir3p is a target of mitogen‐activated protein (MAP) kinase cascade regulation and has significant similarity to the Orc1p subunit of the DNA replication origin recognition complex. Thus, in concert with other silencing proteins, Sir3p appears poised to respond to cellular signals and reprogram silencing through replication‐associated assembly of repressive chromatin structures. BioEssays 20:30–40, 1998. © 1998 John Wiley & Sons, Inc. -/- . (shrink)

This paper will survey and assess the ways in which moral thinkers in the early modern tradition of casuistry considered a range of cases of conscience (casus conscientiae) relating to lying, deception, and witholding the truth. Arguing that the position of the casuists has been unjustly maligned — not least by Pascal's brillant yet partizan Les Proviniciales — casuistical theories of lying and simulation will be placed in a broad intellectual context which will examine attihules to mendacity among early modern (...) medical writers, political theorists, anbl philosophers. Contrasting casuistical theoriessuch as equivocation and mental reservation with the approach to lying of other early modern writers, the lecture will advancfcahe view that the casuists promulgated a conceptual outlook on the differences betweefc lying and deception which is of inherent interest, and which helps to clarify some of the salient issues that attend a philosophical account of lying. (shrink)

Action research is increasingly used as a means for teachers to improve their instruction, yet for many the idea of doing "research" can be somewhat intimidating. _Using Action Research to Improve Instruction_ offers a comprehensive, easy-to-understand approach to action research in classroom settings. This engaging and accessible guide is grounded in sources of data readily available to teachers, such as classroom observations, student writing, surveys, interviews, and tests. Organized to mirror the action research process, the highly interactive format prompts readers (...) to discover a focus, create research questions, address design and methodology, collect information, conduct data analysis, communicate the results, and to generate evidence-based teaching strategies. Engaging in these decision-making processes builds the skills essential to action research and promotes a deeper understanding of teaching practice. Special Features Include: -An Interactive Text -Reflection Questions and Activity Prompts -A Sample Action Research Report -Numerous Examples and Practice Examples -Numbered Sections for Cross Referencing This original text is a must-read for teachers interested in how they can use their current knowledge of instruction and assessment to meaningfully engage in action research. (shrink)

What is the will? And what is its relation to human action? Throughout history, philosophers have been fascinated by the idea of 'the will': the source of the drive that motivates human beings to act. However, there has never been a clear consensus as to what the will is and how it relates to human action. Some philosophers have taken the will to be based firmly in reason and rational choice, and some have seen it as purely self-determined. Others have (...) replaced the idea of the human will with a more general drive uniting humans and the rest of nature, living and non-living. This collection of nine specially commissioned papers trace the formulation and treatment of the problem of the will from ancient philosophy through the scholastic theologians of the Middle Ages, to modern philosophy, and right up to contemporary theories. Philosophers discussed include Plato, Aristotle, Augustine, Aquinas, Bonaventure, Hobbes, Kant, Schopenhauer and Nietzsche. (shrink)

Public Health Science and practice expanded during the course of the 20th century. Initially focused on controlling infectious disease through basic public health programs regulating water, sanitation and food, by 1988 the Institute of Medicine broadly declared that “public health is what we, as a society, do collectively to. assure the conditions for people to be healthy.” Commensurate with this definition, public health practitioners and policymakers today work on ;in enormous range of issues. The 2002 policy agenda of the American (...) Public Health Association reflects positions on genomics’ role in public health; national health and safety standards for child care programs; sodium in Americans’ diets; the health and safety of emergency rescue workers; and war in Central Asia and the Persian Gulf. (shrink)

Public Health Science and practice expanded during the course of the 20th century. Initially focused on controlling infectious disease through basic public health programs regulating water, sanitation and food, by 1988 the Institute of Medicine broadly declared that “public health is what we, as a society, do collectively to. assure the conditions for people to be healthy.” Commensurate with this definition, public health practitioners and policymakers today work on ;in enormous range of issues. The 2002 policy agenda of the American (...) Public Health Association reflects positions on genomics’ role in public health; national health and safety standards for child care programs; sodium in Americans’ diets; the health and safety of emergency rescue workers; and war in Central Asia and the Persian Gulf. (shrink)

The Philosophers' Library features the most important philosophy manuscripts and books as stepping stones to take your through the history of philosophy. By cataloguing the history of philosophy via its key works, this book reflects the physical results of human thinking and endeavour; brilliant thought manifested in titles that literally changed the course of knowledge, sometimes by increments, and sometimes with revolutionary impact. This is a unique book of books, all as beautiful as they are important, whether they be ancient, (...) modern or those in-between"--Publisher's description. (shrink)

In this paper we shall introduce the variety WQS of weak-quasi-Stone algebras as a generalization of the variety QS of quasi-Stone algebras introduced in [9]. We shall apply the Priestley duality developed in [4] for the variety N of ¬-lattices to give a duality for WQS. We prove that a weak-quasi-Stone algebra is characterized by a property of the set of its regular elements, as well by mean of some principal lattice congruences. We will also determine the (...) simple and subdirectly irreducible algebras. (shrink)

In this paper we shall introduce the variety WQS of weak-quasi-Stone algebras as a generalization of the variety QS of quasi-Stone algebras introduced in [9]. We shall apply the Priestley duality developed in [4] for the variety N of ¬-lattices to give a duality for WQS. We prove that a weak-quasi-Stone algebra is characterized by a property of the set of its regular elements, as well by mean of some principal lattice congruences. We will also determine the (...) simple and subdirectly irreducible algebras. (shrink)

In our society, some aspects of life are off-limits to commerce. We prohibit the selling of children and the buying of wives, juries, and kidneys. Tainted blood is an inevitable consequence of paying blood donors; even sophisticated laboratory tests cannot supplant the gift-giving relationship as a safeguard of the purity of blood. Like blood, health care is too precious, intimate, and corruptible to entrust to the market.The hospice movement in the United States is approximately 40 years old. During these past (...) four decades, the concept of holistic, multidisciplinary care for patients who are suffering from a terminal illness has evolved from a modest, grassroots constellation of primarily volunteer-run and community-governed endeavors to a multimillion dollar industry where the surviving nonprofits compete with for-profit providers, often publicly traded, managed by M.B.A.-trained executives, and governed by corporate boards. The relatively recent emergence of for-profit hospice reflects an increasing commercialization of health care in the United States, the potentially adverse impact of which has been well documented. (shrink)

To offer engaging neurorehabilitation training to neurologic patients, motor tasks are often visualized in virtual reality. Recently introduced head-mounted displays allow to realistically mimic the body of the user from a first-person perspective in a highly immersive VR environment. In this immersive environment, users may embody avatars with different body characteristics. Importantly, body characteristics impact how people perform actions. Therefore, alternating body perceptions using immersive VR may be a powerful tool to promote motor activity in neurologic patients. However, the ability (...) of the brain to adapt motor commands based on a perceived modified reality has not yet been fully explored. To fill this gap, we “tricked the brain” using immersive VR and investigated if multisensory feedback modulating the physical properties of an embodied avatar influences motor brain networks and control. Ten healthy participants were immersed in a virtual environment using an HMD, where they saw an avatar from first-person perspective. We slowly transformed the surface of the avatar from human to stone. We enforced this visual change by repetitively touching the real arm of the participant and the arm of the avatar with a hammer, while progressively replacing the sound of the hammer against skin with stone hitting sound via loudspeaker. We applied single-pulse transcranial magnetic simulation to evaluate changes in motor cortical excitability associated with the illusion. Further, to investigate if the “stone illusion” affected motor control, participants performed a reaching task with the human and stone avatar. Questionnaires assessed the subjectively reported strength of embodiment and illusion. Our results show that participants experienced the “stone arm illusion.” Particularly, they rated their arm as heavier, colder, stiffer, and more insensitive when immersed with the stone than human avatar, without the illusion affecting their experienced feeling of body ownership. Further, the reported illusion strength was associated with enhanced motor cortical excitability and faster movement initiations, indicating that participants may have physically mirrored and compensated for the embodied body characteristics of the stone avatar. Together, immersive VR has the potential to influence motor brain networks by subtly modifying the perception of reality, opening new perspectives for the motor recovery of patients. (shrink)

What is the proper relation between the scientific worldview and other parts or aspects of human knowledge and experience? Can any science aim at "complete coverage" of the world, and if it does, will it undermine--in principle or by tendency--other attempts to describe or understand the world? Should morality, theology and other areas resist or be protected from scientific treatment? Questions of this sort have been of pressing philosophical concern since antiquity. The Proper Ambition of Science presents ten particular case (...) studies written by prominent philosophers, looking at how this problem has been approached from the ancient world right up to the present day. Contributors: Bob Sharples, M.W.F. Stone, G.A.J. Rogers, J.R. Milton, Aaron Ridley, Christopher Hookway, Dermot Moran, Thomas E. Uebel, David Papineau, and Nancy Cartwright. (shrink)

The dissertation is composed of five papers, each of which either deals with a topic in contemporary metaphysics or uses concepts central to contemporary metaphysics as part of the machinery of its argument. Three papers deal with the problem of personal identity. In Hume on Identity: A Defense I argue that Hume, in maintaining that we are always mistaken in ascribing identity to persons, is presenting a fundamental metaphysical problem about identity through change, not trying to analyze the way we (...) talk about change as his contemporary critics charge. I explicate Hume's argument for this alarming conclusion and show it is far more powerful than has been realized. In Parfit on Identity, I criticize recent attempts to reduce persons to series of psychophysical states or stages. I outline a Realist account of persons and argue that identity is what matters in survival. In Memories, Brains, and Identity, I attack John Locke's contention that present identity is a function of present experience. I use counter-instances derived from the literature on split-brains to show that my present experience could have belonged to someone else. A consequence is that the memory criterion of personal identity is essentially incomplete. ;Examples from the literature on personal identity involving fissioning are central to Abortion and The Control of Human Bodies in which I argue that an organism with a strong right to life has a right to the continued use of the biological equipment, the use of which it acquires through the species-typical process of its own creation. A consequence is that if a fetus is a person, he has the right to the continued use of the mother's womb whether she has given it to him or not. ;The papers on Locke and Parfit rely upon the apparatus of possible worlds, which is central to Dreaming and Certainty. If I believe that I am in a world in which I have conclusive evidence that I am awake, and there is a possible world in which I have the same belief and it is false, can I know which is actual on the basis of the evidence I believe is conclusive? I argue that being wide-awake is a self-recognizing state: when I'm not in it I can mistakenly believe that I am in it, but when my belief is true, I know it. I argue that this enables me to recognize that I am not dreaming. (shrink)

The traditional paradox of the stone may be interpreted as posing a competition between a pair of omnipotent beings, represented by God at two different times. The new paradox poses a question about simultaneous competition between a pair of omnipotent beings. We make use of an attractive Thomistic response to the former paradox in arguing that the latter situation is logically possible.

Context: Non-dualist philosophy is no longer novel. Arguing against the distinctions between thought and action, theory and practice, language and objects has been a staple of the debate for decades, and Josef Mitterer offers another approach to the problem. Problem: Non-dualist philosophy is beset by a problem: it is trying to argue against a separation of “ideas” from the life-world while staying exclusively on the side of ideas. They offer a philosophy seminar argument against the bread and butter of philosophy (...) seminars. Results: The paper argues that non-dualism in practice is best represented not by philosophers but by everyday life sociologists; not by those who argue against theory and idealisms but by those who simply ignore them. Non-dualism, however, is a practical tool when theorists have to be confronted practically; this, I argue, is their value, and in this debate, they are welcome. It is, however, a value that should not be overstated. (shrink)

Let A be an algebra. We say that the functions f 1 , . . . , f m : A n → A are algebraic on A provided there is a finite system of term-equalities $${{\bigwedge t_{k}(\overline{x}, \overline{z}) = s_{k}(\overline{x}, \overline{z})}}$$ satisfying that for each $${{\overline{a} \in A^{n}}}$$, the m -tuple $${{(f_{1}(\overline{a}), \ldots , f_{m}(\overline{a}))}}$$ is the unique solution in A m to the system $${{\bigwedge t_{k}(\overline{a}, \overline{z}) = s_{k}(\overline{a}, \overline{z})}}$$. In this work we present a collection of general (...) tools for the study of algebraic functions, and apply them to obtain characterizations for algebraic functions on distributive lattices, Stone algebras, finite abelian groups and vector spaces, among other well known algebraic structures. (shrink)

Involutive Stone algebras were introduced by R. Cignoli and M. Sagastume in connection to the theory of $n$-valued Łukasiewicz–Moisil algebras. In this work we focus on the logic that preserves degrees of truth associated to S-algebras named Six. This follows a very general pattern that can be considered for any class of truth structure endowed with an ordering relation, and which intends to exploit many-valuedness focusing on the notion of inference that results from preserving lower bounds of truth values, (...) and hence not only preserving the value $1$. Among other things, we prove that Six is a many-valued logic that can be determined by a finite number of matrices. Besides, we show that Six is a paraconsistent logic. Moreover, we prove that it is a genuine Logic of Formal Inconsistency with a consistency operator that can be defined in terms of the original set of connectives. Finally, we study the proof theory of Six providing a Gentzen calculus for it, which is sound and complete with respect to the logic. (shrink)

This study examines the symbolic use of stone beyond its basic function as a construction material in architecture. It investigates the meaning of stone using Iraqi Kurdistan residential architecture as a case study. The theoretical framework of the study is developed through the content analysis method, by applying Hershberger’s basic model of meaning, and by exploring Krampen’s writings on semiotics in architecture. The relevant theoretical framework was tested through systematic physical observation of selected houses in Iraqi Kurdistan and (...) by using the inductive reasoning method. The study recognises that stone, beyond being a construction material, conveys the symbolic meaning of “power,” “wealth,” and “belonging” in contemporary houses of Iraqi Kurdistan. Based on that, a meaningful situation model was created to evaluate the phenomenon. The model can also be useful in analysing similar cases and research situations. (shrink)

The farthest east on the transcontinental road to China which ancient travellers from the Mediterranean borderlands are known to have attained was reached by a party that made its way as far as the Stone Tower, a station in the region of the Pamirs, not far from the watershed between the Mediterranean and the Yellow Seas. This expedition was organized by a member of an old business family, named and described as The only reference to Maes in ancient literature (...) is in a brief notice by Ptolemy , which he derived from his main source, the geographer Marinus of Tyre. Can we find out anything more about this great entrepreneur? (shrink)

The farthest east on the transcontinental road to China which ancient travellers from the Mediterranean borderlands are known to have attained was reached by a party that made its way as far as the Stone Tower, a station in the region of the Pamirs, not far from the watershed between the Mediterranean and the Yellow Seas. This expedition was organized by a member of an old business family, named and described as The only reference to Maes in ancient literature (...) is in a brief notice by Ptolemy, which he derived from his main source, the geographer Marinus of Tyre. Can we find out anything more about this great entrepreneur? (shrink)